InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smurf1

Summary

InnateDB Protein

IDBP-208406.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smurf1

Protein Name

SMAD specific E3 ubiquitin protein ligase 1

Synonyms

4930431E10Rik; mKIAA1625;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082827

InnateDB Gene

IDBG-208404 (Smurf1)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 227 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	227 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0070411	I-SMAD binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006611	protein export from nucleus
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0016567	protein ubiquitination
GO:0030154	cell differentiation
GO:0030279	negative regulation of ossification
GO:0030509	BMP signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030579	ubiquitin-dependent SMAD protein catabolic process
GO:0032801	receptor catabolic process
GO:0034394	protein localization to cell surface
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process