InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptpn14

Summary

InnateDB Protein

IDBP-208501.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptpn14

Protein Name

protein tyrosine phosphatase, non-receptor type 14

Synonyms

C130080N23Rik; OTTMUSG00000022087; PTP36;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095051

InnateDB Gene

IDBG-208430 (Ptpn14)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0030971	receptor tyrosine kinase binding

Biological Process

GO:0001946	lymphangiogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006470	protein dephosphorylation
GO:0008285	negative regulation of cell proliferation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0046825	regulation of protein export from nucleus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Protein Structure and Domains

PDB ID

MGI:102467

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000299 FERM domain
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR014392 Protein-tyrosine phosphatase, non-receptor type-14, -21
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029021 Protein-tyrosine phosphatase-like
IPR029071 Ubiquitin-related domain

PFAM

PF00102
PF00782
PF09379
PF09380
PF00373

PRINTS

PR00700
PR00935

PIRSF

PIRSF000934

SMART

SM00194
SM00404
SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References