Version 5.4
Mus musculus Gene: Ptpn14
Summary
InnateDB Gene IDBG-208430.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptpn14
Gene Name protein tyrosine phosphatase, non-receptor type 14
Synonyms C130080N23Rik; OTTMUSG00000022087; PTP36
Species Mus musculus
Ensembl Gene ENSMUSG00000026604
Encoded Proteins
IDBP-208434
protein tyrosine phosphatase, non-receptor type 14
IDBP-208501
protein tyrosine phosphatase, non-receptor type 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152104:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:189728268-189876695
Strand Forward strand
Band H6
Transcripts
ENSMUST00000027898 ENSMUSP00000027898
ENSMUST00000097442 ENSMUSP00000095051
ENSMUST00000128275
ENSMUST00000148129
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003712 transcription cofactor activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0001946 lymphangiogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006470 protein dephosphorylation
GO:0008285 negative regulation of cell proliferation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0046825 regulation of protein export from nucleus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000152104
View Gene Order
ENSBTAG00000021553
Not yet available
Cross-References
SwissProt Q62130
TrEMBL Q8CAV9
UniProt Splice Variant
Entrez Gene 19250
UniGene Mm.397361 Mm.4498 Mm.461978
RefSeq XM_006497129 XM_006497130 XM_006497131 XM_006497132 XM_006497133 XM_006497134 NM_008976
OMIM
CCDS CCDS15609
HPRD
IMGT
MGI ID MGI:102467
MGI Symbol Ptpn14
EMBL AC140250 AC140461 AK037646 CH466555 D31842
GenPept BAA06628 BAC29840 EDL13025 EDL13028
RNA Seq Atlas 19250

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca