InnateDB Protein
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IDBP-208541.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Nme2
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Protein Name
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non-metastatic cells 2, protein (NM23B) expressed in
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000021217
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InnateDB Gene
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IDBG-208539 (Nme2)
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Protein Structure
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Function |
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Negatively regulates Rho activity by interacting with AKAP13/LBC. Exhibits histidine protein kinase activity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm. Cell membrane. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in the base region of the oxyntic and pyloric mucosae. {ECO:0000269PubMed:16476741}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
18
[view]
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Protein-Protein |
18
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:97356
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InterPro |
IPR001564
Nucleoside diphosphate kinase
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PFAM |
PF00334
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PRINTS |
PR01243
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PIRSF |
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SMART |
SM00562
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TIGRFAMs |
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Modification |
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SwissProt |
Q01768
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PhosphoSite |
PhosphoSite-Q01768
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TrEMBL |
Q5NC82
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UniProt Splice Variant |
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Entrez Gene |
433968
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UniGene |
Mm.320516
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RefSeq |
NP_032731
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MGI ID |
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MGI Symbol |
Nme2
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OMIM |
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CCDS |
CCDS25246
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HPRD |
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IMGT |
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EMBL |
AK012447
AK150419
AK151262
AK169120
BC066995
BC086892
BC086893
CH466556
EF437324
X68193
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GenPept |
AAH66995
AAH86892
AAH86893
ABS83502
BAB28246
BAE29543
BAE30250
BAE40900
CAA48275
EDL15908
EDL15909
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