InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nme2

Summary

InnateDB Gene

IDBG-208539.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nme2

Gene Name

NME/NM23 nucleoside diphosphate kinase 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020857

Encoded Proteins

IDBP-208541

non-metastatic cells 2, protein (NM23B) expressed in

IDBP-265806

non-metastatic cells 2, protein (NM23B) expressed in

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000243678:
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of \'A\' (encoded by NME1) and \'B\' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:93949814-93956259

Strand

Reverse strand

Band

Transcripts

ENSMUST00000021217	ENSMUSP00000021217
ENSMUST00000072566	ENSMUSP00000103476

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004550	nucleoside diphosphate kinase activity
GO:0004673	protein histidine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0006165	nucleoside diphosphate phosphorylation
GO:0006183	GTP biosynthetic process
GO:0006228	UTP biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0007229	integrin-mediated signaling pathway
GO:0018106	peptidyl-histidine phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0030027	lamellipodium
GO:0071944	cell periphery

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000243678

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

mmu00240

Pyrimidine metabolism pathway

mmu00230

Purine metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00240

Pyrimidine metabolism pathway

hsa00230

Purine metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.320516

RefSeq

NM_001077529 NM_008705 XM_006504950 XM_006544041

OMIM

CCDS

CCDS25246

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas