InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eef2k

Summary

InnateDB Protein

IDBP-208572.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eef2k

Protein Name

eukaryotic elongation factor-2 kinase

Synonyms

C86191; eEF-2K;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046595

InnateDB Gene

IDBG-208568 (Eef2k)

Protein Structure

UniProt Annotation

Function

Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269PubMed:9144159}.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitously expressed. Particularly abundant in skeletal muscle and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004674	protein serine/threonine kinase activity
GO:0004686	elongation factor-2 kinase activity
GO:0005509	calcium ion binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008135	translation factor activity, nucleic acid binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006414	translational elongation
GO:0006468	protein phosphorylation
GO:0031952	regulation of protein autophosphorylation
GO:0046777	protein autophosphorylation