InnateDB Protein
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IDBP-208749.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Scnn1g
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Protein Name
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sodium channel, nonvoltage-gated 1 gamma
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Synonyms
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[g]ENaC;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000000221
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InnateDB Gene
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IDBG-208747 (Scnn1g)
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Protein Structure
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Function |
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
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Subcellular Localization |
Apical cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Note=Apical membrane of epithelial cells. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Lung and kidney.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
11 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:104695
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InterPro |
IPR001873
Na+ channel, amiloride-sensitive
IPR004724
Epithelial sodium channel
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PFAM |
PF00858
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PRINTS |
PR01078
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WU39
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PhosphoSite |
PhosphoSite-Q9WU39
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
20278
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UniGene |
Mm.35247
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RefSeq |
NP_035456
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MGI ID |
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MGI Symbol |
Scnn1g
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OMIM |
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CCDS |
CCDS21803
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HPRD |
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IMGT |
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EMBL |
AF112187
BC021338
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GenPept |
AAD21246
AAH21338
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