InnateDB Protein
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IDBP-208768.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dtl
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Protein Name
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denticleless homolog (Drosophila)
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Synonyms
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2810047L02Rik; 5730564G15Rik; Ramp;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000027933
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InnateDB Gene
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IDBG-208766 (Dtl)
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Protein Structure
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Function |
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1) and SETD8. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. SETD8 degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA- dependent translesion DNA synthesis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Nucleoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Chromosome {ECO:0000250}. Note=Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
32 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1924093
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InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
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PFAM |
PF00400
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PRINTS |
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
Q3TLR7
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PhosphoSite |
PhosphoSite-Q3TLR7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
76843
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UniGene |
Mm.412729
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RefSeq |
NP_084042
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MGI ID |
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MGI Symbol |
Dtl
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OMIM |
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CCDS |
CCDS15621
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HPRD |
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IMGT |
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EMBL |
AB095735
AB095736
AK012919
AK054412
AK133177
AK161401
AK166351
BC060208
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GenPept |
BAB28549
BAC35769
BAC76404
BAC76405
BAE21543
BAE36376
BAE38725
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