InnateDB Protein
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IDBP-208801.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Insm1
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Protein Name
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insulinoma-associated 1
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Synonyms
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IA-1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000092048
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InnateDB Gene
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IDBG-208799 (Insm1)
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Protein Structure
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Function |
Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle- specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation. {ECO:0000269PubMed:16511571, ECO:0000269PubMed:16951258, ECO:0000269PubMed:18094025, ECO:0000269PubMed:18940587, ECO:0000269PubMed:24227653}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:12079283, ECO:0000269PubMed:24227653}.
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Disease Associations |
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Tissue Specificity |
Expressed in adrenal gland. Expressed in the dentate gyrus of the hippocampus and the wall of the lateral ventricle. Expressed in pancreatic and intestinal endocrine cells. {ECO:0000269PubMed:16951258, ECO:0000269PubMed:18094025, ECO:0000269PubMed:18940587}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1859980
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
Q63ZV0
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PhosphoSite |
PhosphoSite-Q63ZV0
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TrEMBL |
Q05BD7
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UniProt Splice Variant |
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Entrez Gene |
53626
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UniGene |
Mm.405334
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RefSeq |
NP_058585
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MGI ID |
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MGI Symbol |
Insm1
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OMIM |
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CCDS |
CCDS16830
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HPRD |
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IMGT |
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EMBL |
AF044669
BC051240
BC082809
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GenPept |
AAD15718
AAH51240
AAH82809
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