Version 5.4
Mus musculus Gene: Insm1
Summary
InnateDB Gene IDBG-208799.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Insm1
Gene Name insulinoma-associated 1
Synonyms IA-1
Species Mus musculus
Ensembl Gene ENSMUSG00000068154
Encoded Proteins
IDBP-208801
insulinoma-associated 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173404:
Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:146221921-146225020
Strand Forward strand
Band G1
Transcripts
ENSMUST00000089257 ENSMUSP00000092048
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001047 core promoter binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0030332 cyclin binding
GO:0031490 chromatin DNA binding
GO:0042826 histone deacetylase binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001933 negative regulation of protein phosphorylation
GO:0003309 type B pancreatic cell differentiation
GO:0003310 pancreatic A cell differentiation
GO:0003323 type B pancreatic cell development
GO:0003358 noradrenergic neuron development
GO:0006351 transcription, DNA-templated
GO:0007049 cell cycle
GO:0008285 negative regulation of cell proliferation
GO:0010468 regulation of gene expression
GO:0030154 cell differentiation
GO:0031018 endocrine pancreas development
GO:0035270 endocrine system development
GO:0042421 norepinephrine biosynthetic process
GO:0043254 regulation of protein complex assembly
GO:0045597 positive regulation of cell differentiation
GO:0060290 transdifferentiation
GO:0061104 adrenal chromaffin cell differentiation
GO:0061549 sympathetic ganglion development
GO:0071158 positive regulation of cell cycle arrest
GO:2000179 positive regulation of neural precursor cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0017053 transcriptional repressor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000173404
View Gene Order
ENSBTAG00000045526
Not yet available
Pathways
NETPATH
REACTOME
REACT_221082
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells pathway
REACT_188576
Developmental Biology pathway
REACT_205507
Regulation of beta-cell development pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13650
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells pathway
REACT_111045
Developmental Biology pathway
REACT_13698
Regulation of beta-cell development pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q63ZV0
TrEMBL Q05BD7
UniProt Splice Variant
Entrez Gene 53626
UniGene Mm.379070 Mm.405334
RefSeq NM_016889
OMIM
CCDS CCDS16830
HPRD
IMGT
MGI ID MGI:1859980
MGI Symbol Insm1
EMBL AF044669 BC051240 BC082809
GenPept AAD15718 AAH51240 AAH82809
RNA Seq Atlas 53626

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca