InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Xrn2

Summary

InnateDB Protein

IDBP-208858.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Xrn2

Protein Name

5'-3' exoribonuclease 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028921

InnateDB Gene

IDBG-208856 (Xrn2)

Protein Structure

UniProt Annotation

Function

Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the spleen, testis, heart, brain, lung, liver, skeletal muscle, and kidney. {ECO:0000269PubMed:7885830}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004527	exonuclease activity
GO:0004534	5'-3' exoribonuclease activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008409	5'-3' exonuclease activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000738	DNA catabolic process, exonucleolytic
GO:0006139	nucleobase-containing compound metabolic process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006353	DNA-dependent transcription, termination
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0007017	microtubule-based process
GO:0007283	spermatogenesis
GO:0016049	cell growth
GO:0016070	RNA metabolic process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic