InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Xrn2

Summary

InnateDB Gene

IDBG-208856.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Xrn2

Gene Name

5'-3' exoribonuclease 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027433

Encoded Proteins

IDBP-208858

5'-3' exoribonuclease 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088930:
This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:147012996-147078000

Strand

Forward strand

Band

Transcripts

ENSMUST00000028921	ENSMUSP00000028921
ENSMUST00000147057
ENSMUST00000136136
ENSMUST00000137358

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004527	exonuclease activity
GO:0004534	5'-3' exoribonuclease activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008409	5'-3' exonuclease activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000738	DNA catabolic process, exonucleolytic
GO:0006139	nucleobase-containing compound metabolic process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006353	DNA-dependent transcription, termination
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0007017	microtubule-based process
GO:0007283	spermatogenesis
GO:0016049	cell growth
GO:0016070	RNA metabolic process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane
GO:0016235	aggresome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000088930

View Gene Order

ENSBTAG00000011304

Not yet available

Pathways

NETPATH

REACTOME

REACT_258900

Chaperonin-mediated protein folding pathway

REACT_244970

Association of TriC/CCT with target proteins during biosynthesis pathway

REACT_247926

Metabolism of proteins pathway

REACT_245534

Protein folding pathway

KEGG

mmu03018

RNA degradation pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_16907

Association of TriC/CCT with target proteins during biosynthesis pathway

REACT_16952

Protein folding pathway

REACT_17004

Chaperonin-mediated protein folding pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa03018

RNA degradation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.3065 Mm.471989

RefSeq

NM_011917

OMIM

CCDS

CCDS38258

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas