InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nxt1

Summary

InnateDB Protein

IDBP-208997.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nxt1

Protein Name

NTF2-related export protein 1

Synonyms

1110001N02Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038329

InnateDB Gene

IDBG-208995 (Nxt1)

Protein Structure

UniProt Annotation

Function

Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Nucleus speckle {ECO:0000250}. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008536	Ran GTPase binding

Biological Process

GO:0006405	RNA export from nucleus
GO:0006611	protein export from nucleus
GO:0006810	transport
GO:0051028	mRNA transport

Cellular Component

GO:0005622	intracellular
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

MGI:1929619

InterPro

IPR002075 Nuclear transport factor 2
IPR018222 Nuclear transport factor 2, eukaryote

PFAM

PF02136

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QZV9

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

56488

UniGene

Mm.365392

RefSeq

NP_062735

MGI ID

MGI Symbol

Nxt1

OMIM

CCDS

CCDS16840

HPRD

IMGT

EMBL

AF156958 AK003254 AK168314 BC023672

GenPept

AAD54943 AAH23672 BAB22670 BAE40254