InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irf6

Summary

InnateDB Protein

IDBP-209075.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irf6

Protein Name

interferon regulatory factor 6

Synonyms

AI876454; E230028I05Rik; mirf6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075839

InnateDB Gene

IDBG-209073 (Irf6)

Protein Structure

UniProt Annotation

Function

Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. {ECO:0000269PubMed:17041603, ECO:0000269PubMed:18212048, ECO:0000269PubMed:19036739, ECO:0000269PubMed:21574244}.

Subcellular Localization

Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269PubMed:19036739}. Note=Translocates to nucleus in response to an activating signal. {ECO:0000305}.

Disease Associations

Tissue Specificity

High levels of expression along the medial edge of the fusing palate, tooth buds, hair follicles, genitalia and skin. {ECO:0000269PubMed:12219090}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0030216	keratinocyte differentiation
GO:0043588	skin development
GO:0043616	keratinocyte proliferation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048468	cell development
GO:0060644	mammary gland epithelial cell differentiation