InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Irf6

Summary

InnateDB Gene

IDBG-209073.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irf6

Gene Name

interferon regulatory factor 6

Synonyms

AI876454; E230028I05Rik; mirf6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026638

Encoded Proteins

IDBP-209075

interferon regulatory factor 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 12219090

[Homo sapiens] IRF6 belongs to a family of transcription factors that share a highly conserved helix-turn-helix DNA-binding domain and a less conserved protein-binding domain.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117595:
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:193153112-193172042

Strand

Forward strand

Band

Transcripts

ENSMUST00000076521	ENSMUSP00000075839
ENSMUST00000138826
ENSMUST00000140066

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0030216	keratinocyte differentiation
GO:0043588	skin development
GO:0043616	keratinocyte proliferation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048468	cell development
GO:0060644	mammary gland epithelial cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000117595

View Gene Order

ENSBTAG00000002849

Not yet available

Pathways

NETPATH

REACTOME

REACT_233584

Cytokine Signaling in Immune system pathway

REACT_230745

Immune System pathway

REACT_198660

Interferon gamma signaling pathway

REACT_198666

Interferon Signaling pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_25162

Interferon alpha/beta signaling pathway

REACT_25078

Interferon gamma signaling pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_25229

Interferon Signaling pathway

REACT_6900

Immune System pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P97431

TrEMBL

UniProt Splice Variant

Entrez Gene

54139

UniGene

Mm.273695

RefSeq

NM_016851 XM_006497262 XM_006497263

OMIM

CCDS

CCDS15632

HPRD

IMGT

MGI ID

MGI:1859211

MGI Symbol

Irf6

EMBL

AK143299 AK143954 AL365322 BC008515 CH466555 U73029

GenPept

AAB36714 AAH08515 BAE25338 BAE25628 CAX15615 EDL12956

RNA Seq Atlas

54139