InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aqp8

Summary

InnateDB Protein

IDBP-209162.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aqp8

Protein Name

aquaporin 8

Synonyms

AI255744; AQP-8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033023

InnateDB Gene

IDBG-209160 (Aqp8)

Protein Structure

UniProt Annotation

Function

Forms a water-specific channel; mercury-sensitive. Also permeable to urea but not to glycerol.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Colon, liver, heart and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0015250	water channel activity

Biological Process

GO:0006810	transport
GO:0006833	water transport
GO:0015722	canalicular bile acid transport
GO:0071320	cellular response to cAMP

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0045177	apical part of cell
GO:0046691	intracellular canaliculus

Protein Structure and Domains

PDB ID

MGI:1195271

InterPro

IPR000425 Major intrinsic protein
IPR023271 Aquaporin-like
IPR023277 Aquaporin 8

PFAM

PF00230

PRINTS

PR00783
PR02020

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P56404

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

11833

UniGene

Mm.273175

RefSeq

NP_031500

MGI ID

MGI Symbol

Aqp8

OMIM

CCDS

CCDS72038

HPRD

IMGT

EMBL

AF018952 AF107538 AF107539 AF107540 AF107541 AF107542 AF107543 BC010982

GenPept

AAB68847 AAD55972 AAH10982