InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Jmjd5

Summary

InnateDB Protein

IDBP-209238.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Jmjd5

Protein Name

jumonji domain containing 5

Synonyms

3110005O21Rik; Jmjd5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033010

InnateDB Gene

IDBG-209236 (Jmjd5)

Protein Structure

UniProt Annotation

Function

Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1) (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003682	chromatin binding
GO:0046872	metal ion binding
GO:0051864	histone demethylase activity (H3-K36 specific)

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0008150	biological_process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process
GO:0070544	histone H3-K36 demethylation