Version 5.4
Mus musculus Protein: Abhd12
Summary
InnateDB Protein IDBP-209410.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Abhd12
Protein Name abhydrolase domain containing 12
Synonyms 1500011G07Rik; 6330583M11Rik; AI431047; AW547313;
Species Mus musculus
Ensembl Protein ENSMUSP00000053558
InnateDB Gene IDBG-209406 (Abhd12)
Protein Structure
UniProt Annotation
Function Lysophosphatidylserine (LPS) lipase, that plays a key role in the central nervous system. Represents a major LPS lipase in the brain (PubMed:23297193). Has 2-arachidonoylglycerol (2-AG) hydrolase activity. May act as a regulator of endocannabinoid signaling pathways (PubMed:18096503). {ECO:0000269PubMed:18096503, ECO:0000269PubMed:23297193}.
Subcellular Localization Membrane {ECO:0000269PubMed:18096503}; Single-pass membrane protein {ECO:0000269PubMed:18096503}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0047372 acylglycerol lipase activity
Biological Process
GO:0006660 phosphatidylserine catabolic process
GO:0007628 adult walking behavior
GO:0008152 metabolic process
GO:0010996 response to auditory stimulus
Cellular Component
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
Protein Structure and Domains
PDB ID MGI:1923442
InterPro IPR000073 Alpha/beta hydrolase fold-1
IPR013094 Alpha/beta hydrolase fold-3
IPR029058 Alpha/Beta hydrolase fold
PFAM PF00561
PF07859
PRINTS PR00111
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99LR1
PhosphoSite PhosphoSite-Q99LR1
TrEMBL
UniProt Splice Variant
Entrez Gene 76192
UniGene
RefSeq NP_077785
MGI ID
MGI Symbol Abhd12
OMIM
CCDS CCDS50742
HPRD
IMGT
EMBL AL808125 AL954712 BC002138 BC002263 CH466519
GenPept AAH02138 AAH02263 CAM17128 CAM18377 EDL28584

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca