InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tac4

Summary

InnateDB Protein

IDBP-209536.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tac4

Protein Name

tachykinin 4

Synonyms

AW489379; PPT-C;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021242

InnateDB Gene

IDBG-209534 (Tac4)

Protein Structure

UniProt Annotation

Function

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Hemokinin induces plasma extravasation, mast cell degranulation, muscle contraction, salivary secretion and scratching behavior. Increases sperm motility. Induces potent analgesic effects and may play a role in pain modulation. Promotes survival of bone marrow B lineage cells and of cultured LPS- stimulated pre-B cells and may act as an autocrine factor required for B-cell survival and proliferation. Lowers systemic arterial pressure following intravenous injection. Induces interferon-gamma production and may play a role in the inflammatory response. Shows potent affinity and specificity for the NK-1 receptor. {ECO:0000269PubMed:11062498, ECO:0000269PubMed:11725292, ECO:0000269PubMed:11786503, ECO:0000269PubMed:12044836, ECO:0000269PubMed:12842130, ECO:0000269PubMed:15153465, ECO:0000269PubMed:16102736, ECO:0000269PubMed:17628523}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in hematopoietic cells with highest levels in pre- and pro-B cells but not in later developmental stages. Also detected in uterus, skeletal muscle, brain, spleen, stomach, skin and lactating mammary gland and in cells of myeloid lineage including dendritic and microglial cells and macrophages. In uterus, highest expression is observed in non-pregnant diestrus mice and in day 5 pregnant mice. Compared with mice in diestrus, decreases 2.6-fold in uteri from non-pregnant mice in estrus and 10.2-fold in day 17 pregnant mice. Detected at sites of chronic inflammation such as granulomas. {ECO:0000269PubMed:11062498, ECO:0000269PubMed:12383518, ECO:0000269PubMed:12716968, ECO:0000269PubMed:12842130, ECO:0000269PubMed:15153465, ECO:0000269PubMed:15342200, ECO:0000269PubMed:15647454}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding

Biological Process

GO:0007217	tachykinin receptor signaling pathway
GO:0008217	regulation of blood pressure
GO:0043303	mast cell degranulation
GO:0046878	positive regulation of saliva secretion