Version 5.4
Mus musculus Protein: Tufm
Summary
InnateDB Protein IDBP-209546.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tufm
Protein Name Tu translation elongation factor, mitochondrial
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000095656
InnateDB Gene IDBG-209544 (Tufm)
Protein Structure
UniProt Annotation
Function This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}.
Subcellular Localization Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 87 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 87 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006414 translational elongation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Protein Structure and Domains
PDB ID MGI:1923686
InterPro IPR000795 Elongation factor, GTP-binding domain
IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle
IPR009000 Translation protein, beta-barrel domain
IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00009
PF03143
PF03144
PRINTS PR00315
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BFR5
PhosphoSite PhosphoSite-Q8BFR5
TrEMBL
UniProt Splice Variant
Entrez Gene 233870
UniGene Mm.197829
RefSeq NP_766333
MGI ID
MGI Symbol Tufm
OMIM
CCDS CCDS21830
HPRD
IMGT
EMBL AK075857 AK084724 AK152858 AK153135 BC060959 BC100596
GenPept AAH60959 AAI00597 BAC36008 BAC39263 BAE31551 BAE31747

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca