Version 5.4
Mus musculus Gene: Tufm
Summary
InnateDB Gene IDBG-209544.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tufm
Gene Name Tu translation elongation factor, mitochondrial
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000073838
Encoded Proteins
IDBP-209546
Tu translation elongation factor, mitochondrial
IDBP-268864
Tu translation elongation factor, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22749352
Tufm inhibits RLR-induced IFN-I and promotes autophagy during viral infection. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 22749352
[Homo sapiens] TUFM inhibits RLR-induced IFN-I and promotes autophagy during viral infection.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178952:
This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:126487355-126490730
Strand Forward strand
Band F3
Transcripts
ENSMUST00000098048 ENSMUSP00000095656
ENSMUST00000106392 ENSMUSP00000102000
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 87 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 87 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006414 translational elongation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000178952
View Gene Order
ENSBTAG00000019216
Not yet available
Pathways
NETPATH
REACTOME
REACT_268789
Mitochondrial translation pathway
REACT_224594
Organelle biogenesis and maintenance pathway
REACT_270125
Mitochondrial translation elongation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_267673
Mitochondrial translation pathway
REACT_267677
Mitochondrial translation elongation pathway
REACT_271447
Mitochondrial translation elongation pathway
REACT_270450
Mitochondrial translation pathway
REACT_219259
Organelle biogenesis and maintenance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8BFR5
TrEMBL
UniProt Splice Variant
Entrez Gene 233870
UniGene Mm.197829
RefSeq NM_001163713 NM_172745
OMIM
CCDS CCDS52398 CCDS21830
HPRD
IMGT
MGI ID MGI:1923686
MGI Symbol Tufm
EMBL AK075857 AK084724 AK152858 AK153135 BC060959 BC100596
GenPept AAH60959 AAI00597 BAC36008 BAC39263 BAE31551 BAE31747
RNA Seq Atlas 233870

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca