InnateDB Protein
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IDBP-209635.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pds5b
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Protein Name
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PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
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Synonyms
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AI646570; Aprin; AS3; AW212954; mKIAA0979;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000016569
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InnateDB Gene
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IDBG-209633 (Pds5b)
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Protein Structure
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Function |
Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250UniProtKB:Q6TRW4}.
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Disease Associations |
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Tissue Specificity |
Expressed in prostate. {ECO:0000269Ref.1}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
27 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2140945
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InterPro |
IPR016024
Armadillo-type fold
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q4VA53
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PhosphoSite |
PhosphoSite-Q4VA53
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
100710
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UniGene |
Mm.473022
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RefSeq |
NP_780519
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MGI ID |
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MGI Symbol |
Pds5b
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OMIM |
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CCDS |
CCDS39412
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HPRD |
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IMGT |
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EMBL |
AK041682
AK045159
AK048706
AK122414
AK164853
AY102267
BC096539
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GenPept |
AAH96539
AAM52216
BAC31031
BAC32242
BAC33427
BAC65696
BAE37943
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