Version 5.4
Mus musculus Gene: Pds5b
Summary
InnateDB Gene IDBG-209633.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pds5b
Gene Name PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
Synonyms AI646570; Aprin; AS3; AW212954; mKIAA0979
Species Mus musculus
Ensembl Gene ENSMUSG00000034021
Encoded Proteins
IDBP-209635
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
IDBP-209637
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
IDBP-260167
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000083642:
This gene encodes a protein that interacts with the conserved protein complex termed cohesion. The cohesion complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:150673739-150810690
Strand Forward strand
Band G3
Transcripts
ENSMUST00000016569 ENSMUSP00000016569
ENSMUST00000038900 ENSMUSP00000038421
ENSMUST00000110486 ENSMUSP00000106112
ENSMUST00000133738
ENSMUST00000154083
ENSMUST00000132947
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0007064 mitotic sister chromatid cohesion
GO:0008285 negative regulation of cell proliferation
GO:0042127 regulation of cell proliferation
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000083642
View Gene Order
ENSBTAG00000011597
Not yet available
Pathways
NETPATH
REACTOME
REACT_249770
Cell Cycle, Mitotic pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_250427
Mitotic Telophase/Cytokinesis pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_196634
Cohesin Loading onto Chromatin pathway
REACT_196614
Establishment of Sister Chromatid Cohesion pathway
REACT_202512
Mitotic Anaphase pathway
REACT_253623
S Phase pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_150421
Cohesin Loading onto Chromatin pathway
REACT_1932
Mitotic Telophase/Cytokinesis pathway
REACT_150266
Establishment of Sister Chromatid Cohesion pathway
REACT_899
S Phase pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q4VA53
TrEMBL
UniProt Splice Variant
Entrez Gene 100710
UniGene Mm.32959 Mm.473022
RefSeq NM_175310 XM_006504901 XM_006504902 XM_006504903 XM_006504905
OMIM
CCDS CCDS39412
HPRD
IMGT
MGI ID MGI:2140945
MGI Symbol Pds5b
EMBL AK041682 AK045159 AK048706 AK122414 AK164853 AY102267 BC096539
GenPept AAH96539 AAM52216 BAC31031 BAC32242 BAC33427 BAC65696 BAE37943
RNA Seq Atlas 100710

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca