Version 5.4
| Mus musculus Protein: Doc2a | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-209885.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Doc2a | ||||||||
| Protein Name | double C2, alpha | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000070119 | ||||||||
| InnateDB Gene | IDBG-209883 (Doc2a) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269PubMed:18354201, ECO:0000269PubMed:20150444}. | ||||||||
| Subcellular Localization | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Lysosome {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Brain and mast cells. {ECO:0000269PubMed:18354201}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:109446 | ||||||||
| InterPro |
IPR000008
C2 domain IPR001565 Synaptotagmin IPR014638 Double C2 protein, alpha/beta/gamma type |
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| PFAM |
PF00168
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| PRINTS |
PR00360
PR00399 |
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| PIRSF |
PIRSF036931
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| SMART |
SM00239
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q7TNF0 | ||||||||
| PhosphoSite | PhosphoSite-Q7TNF0 | ||||||||
| TrEMBL | D3Z1K1 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 13446 | ||||||||
| UniGene | Mm.490525 | ||||||||
| RefSeq | NP_034199 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Doc2a | ||||||||
| OMIM | |||||||||
| CCDS | CCDS21847 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AC124505 BC055768 | ||||||||
| GenPept | AAH55768 | ||||||||