InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cbx1

Summary

InnateDB Protein

IDBP-209989.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cbx1

Protein Name

chromobox homolog 1 (Drosophila HP1 beta)

Synonyms

Cbx; Cbx-rs2; E430007M08Rik; HP1B; Hp1beta; M31; MOD1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091475

InnateDB Gene

IDBG-209987 (Cbx1)

Protein Structure

UniProt Annotation

Function

Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Unassociated with chromosomes during mitosis. {ECO:0000250}.

Disease Associations

Tissue Specificity

In all adult and embryonic tissues. {ECO:0000269PubMed:1708124}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	59 [view]
Protein-Protein	59 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:1990226	histone methyltransferase binding

Biological Process

GO:0045892

negative regulation of transcription, DNA-templated

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000785	chromatin
GO:0001939	female pronucleus
GO:0001940	male pronucleus
GO:0005634	nucleus
GO:0005721	centromeric heterochromatin
GO:0005819	spindle
GO:0010369	chromocenter