InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnmt3b

Summary

InnateDB Protein

IDBP-210144.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Dnmt3b

Protein Name

DNA methyltransferase 3B

Synonyms

MmuIIIB;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051830

InnateDB Gene

IDBG-210140 (Dnmt3b)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	24 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0003886	DNA (cytosine-5-)-methyltransferase activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0045322	unmethylated CpG binding
GO:0051718	DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006306	DNA methylation
GO:0006346	methylation-dependent chromatin silencing
GO:0006349	regulation of gene expression by genetic imprinting
GO:0010212	response to ionizing radiation
GO:0010424	DNA methylation on cytosine within a CG sequence
GO:0010628	positive regulation of gene expression
GO:0031503	protein complex localization
GO:0042493	response to drug
GO:0045666	positive regulation of neuron differentiation
GO:0046498	S-adenosylhomocysteine metabolic process
GO:0046499	S-adenosylmethioninamine metabolic process
GO:0051571	positive regulation of histone H3-K4 methylation
GO:0051573	negative regulation of histone H3-K9 methylation
GO:0071230	cellular response to amino acid stimulus
GO:0090116	C-5 methylation of cytosine

Cellular Component

GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005720	nuclear heterochromatin
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1261819

InterPro

IPR000313 PWWP domain
IPR001525 C-5 cytosine methyltransferase
IPR011011 Zinc finger, FYVE/PHD-type
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF00855
PF00145

PRINTS

PR00105

PIRSF

SMART

SM00293

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt