InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnmt3b

Summary

InnateDB Protein

IDBP-210146.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnmt3b

Protein Name

DNA methyltransferase 3B

Synonyms

MmuIIIB;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080334

InnateDB Gene

IDBG-210140 (Dnmt3b)

Protein Structure

UniProt Annotation

Function

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co- repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Function as transcriptional corepressor by associating with ZHX1 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15456878}. Note=Accumulates in the major satellite repeats at pericentric heterochromatin.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	24 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003886	DNA (cytosine-5-)-methyltransferase activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006306	DNA methylation
GO:0006346	methylation-dependent chromatin silencing
GO:0006349	regulation of gene expression by genetic imprinting
GO:0031503	protein complex localization
GO:0043045	DNA methylation involved in embryo development
GO:0045814	negative regulation of gene expression, epigenetic
GO:0071230	cellular response to amino acid stimulus
GO:0090116	C-5 methylation of cytosine

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005720	nuclear heterochromatin

Protein Structure and Domains

PDB ID

MGI:1261819

InterPro

IPR000313 PWWP domain
IPR001525 C-5 cytosine methyltransferase
IPR011011 Zinc finger, FYVE/PHD-type
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF00855
PF00145

PRINTS

PR00105

PIRSF

SMART

SM00293

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt