Version 5.4
Mus musculus Protein: Npepps
Summary
InnateDB Protein IDBP-210186.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Npepps
Protein Name aminopeptidase puromycin sensitive
Synonyms AAP-S; goku; MP100; Psa; R74825;
Species Mus musculus
Ensembl Protein ENSMUSP00000001480
InnateDB Gene IDBG-210184 (Npepps)
Protein Structure
UniProt Annotation
Function Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. {ECO:0000269PubMed:7592939}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:7592939}. Nucleus {ECO:0000269PubMed:7592939}.
Disease Associations
Tissue Specificity Widely expressed. Highest expression in brain, particularly the striatum and hippocampus. Expressed in Sertoli cells. {ECO:0000269PubMed:10407043, ECO:0000269PubMed:11376114, ECO:0000269PubMed:7592939}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1101358
InterPro IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
PFAM PF01433
PRINTS PR00756
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q11011
PhosphoSite PhosphoSite-Q11011
TrEMBL
UniProt Splice Variant
Entrez Gene 19155
UniGene Mm.417516
RefSeq NP_032968
MGI ID
MGI Symbol Npepps
OMIM
CCDS CCDS25317
HPRD
IMGT
EMBL AK133898 AL627445 BC009653 BC086798 BC098212 CH466556 U35646
GenPept AAC52409 AAH09653 AAH86798 AAH98212 BAE21917 CAM26998 EDL16075

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca