Mus musculus Gene: Npepps
Summary
InnateDB Gene IDBG-210184.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Npepps
Gene Name aminopeptidase puromycin sensitive
Synonyms AAP-S; goku; MP100; Psa; R74825
Species Mus musculus
Ensembl Gene ENSMUSG00000001441
Encoded Proteins
aminopeptidase puromycin sensitive
aminopeptidase puromycin sensitive
aminopeptidase puromycin sensitive
aminopeptidase puromycin sensitive
aminopeptidase puromycin sensitive
aminopeptidase puromycin sensitive
aminopeptidase puromycin sensitive
aminopeptidase puromycin sensitive
aminopeptidase puromycin sensitive
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141279:
This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:97205842-97280638
Strand Reverse strand
Band D
Transcripts
ENSMUST00000001480 ENSMUSP00000001480
ENSMUST00000109294
ENSMUST00000107608
ENSMUST00000133907
ENSMUST00000147287
ENSMUST00000152820
ENSMUST00000154372 ENSMUSP00000119644
ENSMUST00000146833
ENSMUST00000154917 ENSMUSP00000127631
ENSMUST00000152546 ENSMUSP00000129623
ENSMUST00000167806 ENSMUSP00000130445
ENSMUST00000172108 ENSMUSP00000127801
ENSMUST00000165489
ENSMUST00000165216 ENSMUSP00000128169
ENSMUST00000171320
ENSMUST00000170506
ENSMUST00000163164 ENSMUSP00000129361
ENSMUST00000168743 ENSMUSP00000127127
ENSMUST00000163950
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Class I MHC mediated antigen processing & presentation pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Adaptive Immune System pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Antigen processing: Ubiquitination & Proteasome degradation pathway
Adaptive Immune System pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.29824 Mm.408980 Mm.417516
RefSeq NM_008942 XM_006532512
OMIM
CCDS CCDS25317
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas