InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bpifa1

Summary

InnateDB Protein

IDBP-210273.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bpifa1

Protein Name

BPI fold containing family A, member 1

Synonyms

LUNX; NASG; Plunc; SPLUNC1; SPURT;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028985

InnateDB Gene

IDBG-210271 (Bpifa1)

Protein Structure

UniProt Annotation

Function

Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (By similarity). Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression. {ECO:0000250, ECO:0000269PubMed:23499554}.

Subcellular Localization

Secreted {ECO:0000269PubMed:23499554}. Note=Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.

Disease Associations

Tissue Specificity

Detected in airway epitelia (trachea and lung) and in bronchoalveolar fluid (at protein level). Upper airways, nasopharyngeal epithelium and thymus. Highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways. No expression is detected in the terminal bronchioles, respiratory bronchioles or lung alveoli. {ECO:0000269PubMed:10224143, ECO:0000269PubMed:11396972, ECO:0000269PubMed:23499554}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0008289	lipid binding

Biological Process

GO:0019731	antibacterial humoral response
GO:0045087	innate immune response (InnateDB)
GO:0050828	regulation of liquid surface tension
GO:0050891	multicellular organismal water homeostasis
GO:1900229	negative regulation of single-species biofilm formation in or on host organism
GO:1902305	regulation of sodium ion transmembrane transport