InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bpifb1

Summary

InnateDB Protein

IDBP-210293.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bpifb1

Protein Name

BPI fold containing family B, member 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080501

InnateDB Gene

IDBG-210291 (Bpifb1)

Protein Structure

UniProt Annotation

Function

May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS. May be involved in formation of the left-right axis in the node of the developing embryo. {ECO:0000269PubMed:14745963, ECO:0000269PubMed:15028288}.

Subcellular Localization

Secreted {ECO:0000269PubMed:14745963}.

Disease Associations

Tissue Specificity

Expressed in tongue, lung, thymus, and stomach. Expressed in epithelia of palate, anterior pharynx, trachea and upper bronchi. Expressed in distal tip of papillae in the anterior third of the tongue and in serous cells of von Ebner glands in the posterior third of the tongue. Expressed in columnar epithelium of the duodenum in embryonic gut at 16.5 dpc. {ECO:0000269PubMed:14745963, ECO:0000269PubMed:15028288}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008289	lipid binding

Biological Process

GO:0002227	innate immune response in mucosa
GO:0034144	negative regulation of toll-like receptor 4 signaling pathway
GO:0045087	innate immune response

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:2137431

InterPro

IPR001124 Lipid-binding serum glycoprotein, C-terminal
IPR017942 Lipid-binding serum glycoprotein, N-terminal
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain
IPR021193 PLUNC, long form

PFAM

PF02886
PF01273

PRINTS

PIRSF

PIRSF037186

SMART

SM00329
SM00328

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt