InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pcgf2

Summary

InnateDB Protein

IDBP-210302.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pcgf2

Protein Name

polycomb group ring finger 2

Synonyms

mel-18; Mel18; Rnf110; Zfp144;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099437

InnateDB Gene

IDBG-210296 (Pcgf2)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex. {ECO:0000269PubMed:11750047, ECO:0000269PubMed:15183898, ECO:0000269PubMed:15728456, ECO:0000269PubMed:16359901, ECO:0000269PubMed:8625838}.

Subcellular Localization

Nucleus.

Disease Associations

Note=Probably related to tumorigenesis since it is expressed strongly in most tumor cell lines.

Tissue Specificity

Expressed in a variety of tumor cells and in neural tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	25 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0006351	transcription, DNA-templated
GO:0009952	anterior/posterior pattern specification
GO:0016573	histone acetylation
GO:0048704	embryonic skeletal system morphogenesis
GO:0048706	embryonic skeletal system development
GO:0070301	cellular response to hydrogen peroxide
GO:2001234	negative regulation of apoptotic signaling pathway