Version 5.4
Mus musculus Gene: Pcgf2
Summary
InnateDB Gene IDBG-210296.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pcgf2
Gene Name polycomb group ring finger 2
Synonyms mel-18; Mel18; Rnf110; Zfp144
Species Mus musculus
Ensembl Gene ENSMUSG00000018537
Encoded Proteins
IDBP-210298
polycomb group ring finger 2
IDBP-210300
polycomb group ring finger 2
IDBP-210302
polycomb group ring finger 2
IDBP-623342
polycomb group ring finger 2
IDBP-717015
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:97688823-97700497
Strand Reverse strand
Band D
Transcripts
ENSMUST00000103149 ENSMUSP00000099438
ENSMUST00000018681 ENSMUSP00000018681
ENSMUST00000103148 ENSMUSP00000099437
ENSMUST00000134003
ENSMUST00000126185
ENSMUST00000169807 ENSMUSP00000126967
ENSMUST00000179765 ENSMUSP00000137517
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 25 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 49 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0006351 transcription, DNA-templated
GO:0009952 anterior/posterior pattern specification
GO:0016573 histone acetylation
GO:0048704 embryonic skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0070301 cellular response to hydrogen peroxide
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0000790 nuclear chromatin
GO:0001739 sex chromatin
GO:0005634 nucleus
GO:0016604 nuclear body
GO:0031519 PcG protein complex
GO:0035102 PRC1 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
null
View Gene Order
ENSBTAG00000011539
Not yet available
Cross-References
SwissProt P23798
TrEMBL B1AR14
UniProt Splice Variant
Entrez Gene 22658
UniGene Mm.2418
RefSeq NM_001163308 XM_006533176 NM_001163307 NM_009545 XM_006533175 XM_006533177
OMIM
CCDS CCDS25327
HPRD
IMGT
MGI ID MGI:99161
MGI Symbol Pcgf2
EMBL AF483502 AF483503 AL596123 BC016419 D90085
GenPept AAH16419 AAL90776 AAL90777 BAA14122
RNA Seq Atlas 22658

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca