InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hsd3b7

Summary

InnateDB Protein

IDBP-210383.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hsd3b7

Protein Name

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

Synonyms

AI195443; BB098564;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036245

InnateDB Gene

IDBG-210381 (Hsd3b7)

Protein Structure

UniProt Annotation

Function

The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Predominantly expressed in liver. {ECO:0000269PubMed:11067870}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0008831	dTDP-4-dehydrorhamnose reductase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0047016	cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity
GO:0050662	coenzyme binding

Biological Process

GO:0006694	steroid biosynthetic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0044237	cellular metabolic process
GO:0045226	extracellular polysaccharide biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2141879

InterPro

IPR001509 NAD-dependent epimerase/dehydratase
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR003869 Polysaccharide biosynthesis protein, CapD-like domain
IPR005913 dTDP-4-dehydrorhamnose reductase
IPR008030 NmrA-like
IPR013120 Male sterility, NAD-binding
IPR013968 Polyketide synthase, KR

PFAM