InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stx4a

Summary

InnateDB Protein

IDBP-210406.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stx4a

Protein Name

syntaxin 4A (placental)

Synonyms

Stx4; Syn-4; Syn4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033075

InnateDB Gene

IDBG-210404 (Stx4a)

Protein Structure

UniProt Annotation

Function

Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones. {ECO:0000269PubMed:10394363, ECO:0000269PubMed:18827011, ECO:0000269PubMed:9045631}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005484	SNAP receptor activity
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0016079	synaptic vesicle exocytosis
GO:0016192	vesicle-mediated transport
GO:0035493	SNARE complex assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0031201	SNARE complex
GO:0035749	myelin sheath adaxonal region
GO:0042581	specific granule
GO:0043219	lateral loop
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome