InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: VKORC1

Summary

InnateDB Protein

IDBP-210440.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VKORC1

Protein Name

vitamin K epoxide reductase complex, subunit 1

Synonyms

D7Wsu86e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033074

InnateDB Gene

IDBG-717692 (VKORC1)

Protein Structure

UniProt Annotation

Function

Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. {ECO:0000269PubMed:15879509, ECO:0000269PubMed:19492146}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in liver. {ECO:0000269PubMed:19492146}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 73 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	73 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity
GO:0048038	quinone binding

Biological Process

GO:0007596	blood coagulation
GO:0017187	peptidyl-glutamic acid carboxylation
GO:0042371	vitamin K biosynthetic process
GO:0042373	vitamin K metabolic process
GO:0050820	positive regulation of coagulation
GO:0055114	oxidation-reduction process
GO:0060348	bone development