InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ahcy

Summary

InnateDB Protein

IDBP-210513.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ahcy

Protein Name

S-adenosylhomocysteine hydrolase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000061851

InnateDB Gene

IDBG-210511 (Ahcy)

Protein Structure

UniProt Annotation

Function

Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.

Subcellular Localization

Cytoplasm. Melanosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004013	adenosylhomocysteinase activity
GO:0004455	ketol-acid reductoisomerase activity
GO:0005515	protein binding
GO:0051287	NAD binding

Biological Process

GO:0006730	one-carbon metabolic process
GO:0008652	cellular amino acid biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0042470

melanosome

Protein Structure and Domains

PDB ID

MGI:87968

InterPro

IPR000043 Adenosylhomocysteinase
IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding
IPR013116 Acetohydroxy acid isomeroreductase, catalytic
IPR015878 S-adenosyl-L-homocysteine hydrolase, NAD binding domain

PFAM

PF05221
PF02826
PF07991
PF00670

PRINTS

PIRSF

PIRSF001109

SMART

SM00996
SM00997

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt