InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP6

Summary

InnateDB Protein

IDBP-21054.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP6

Protein Name

ubiquitin specific peptidase 6 (Tre-2 oncogene)

Synonyms

HRP1; Tre-2; TRE17; TRE2; TRESMCR; USP6-short;

Species

Homo sapiens

Ensembl Protein

ENSP00000250066

InnateDB Gene

IDBG-21050 (USP6)

Protein Structure

UniProt Annotation

Function

Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. {ECO:0000269PubMed:15509780, ECO:0000269PubMed:16127172, ECO:0000269PubMed:20418905}.

Subcellular Localization

Cell membrane. Cytoplasm. Endosome. Note=Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.

Disease Associations

Note=A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with CDH11. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.

Tissue Specificity

Testis specific. Expressed in various cancer cell lines. {ECO:0000269PubMed:12604796, ECO:0000269PubMed:1565468}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004197	cysteine-type endopeptidase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005097	Rab GTPase activator activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016579	protein deubiquitination
GO:0032313	regulation of Rab GTPase activity
GO:0032851	positive regulation of Rab GTPase activity
GO:0060627	regulation of vesicle-mediated transport

Cellular Component

GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005886	plasma membrane
GO:0055037	recycling endosome

Protein Structure and Domains

PDB ID

InterPro

IPR000195 Rab-GTPase-TBC domain
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00566
PF00443

PRINTS

PIRSF

SMART

SM00164

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35125