InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ikzf3

Summary

InnateDB Protein

IDBP-210627.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ikzf3

Protein Name

IKAROS family zinc finger 3

Synonyms

5830411O07Rik; Aiolos; Zfpn1a3; Znfn1a3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099430

InnateDB Gene

IDBG-210625 (Ikzf3)

Protein Structure

UniProt Annotation

Function

Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Binds to GGGAA. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. {ECO:0000269PubMed:9155026, ECO:0000269PubMed:9806640}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9155026}. Cytoplasm {ECO:0000269PubMed:9155026}.

Disease Associations

Tissue Specificity

Expression is restricted to lymphoid tissues. Expressed at highest levels in spleen and at lower levels in the thymus and bone marrow. First detected in more committed lymphoid progenitors and strongly up-regulated as these differentiate into pre-T and pre-B cell precursors. {ECO:0000269PubMed:9155026}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030888	regulation of B cell proliferation
GO:0042113	B cell activation
GO:0042981	regulation of apoptotic process
GO:0045577	regulation of B cell differentiation
GO:0045619	regulation of lymphocyte differentiation