InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ikzf3

Summary

InnateDB Gene

IDBG-210625.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ikzf3

Gene Name

IKAROS family zinc finger 3

Synonyms

5830411O07Rik; Aiolos; Zfpn1a3; Znfn1a3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018168

Encoded Proteins

IDBP-210627

IKAROS family zinc finger 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161405:
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:98464902-98546031

Strand

Reverse strand

Band

Transcripts

ENSMUST00000103141	ENSMUSP00000099430
ENSMUST00000153902
ENSMUST00000140876
ENSMUST00000152400

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030888	regulation of B cell proliferation
GO:0042113	B cell activation
GO:0042981	regulation of apoptotic process
GO:0045577	regulation of B cell differentiation
GO:0045619	regulation of lymphocyte differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000161405

View Gene Order

ENSBTAG00000011003

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

il2_1pathway

IL2-mediated signaling events

Cross-References

SwissProt

O08900

TrEMBL

Q3V3P9

UniProt Splice Variant

Entrez Gene

22780

UniGene

Mm.459157

RefSeq

NM_011771 XM_006533204

OMIM

CCDS

CCDS25352

HPRD

IMGT

MGI ID

MGI:1342542

MGI Symbol

Ikzf3

EMBL

AF001293 AK037261 AL591125 AL591390 CH466556

GenPept

AAB58795 BAE20507 CAM22013 CAM24385 EDL16146

RNA Seq Atlas

22780