InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Thra

Summary

InnateDB Protein

IDBP-210750.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Thra

Protein Name

thyroid hormone receptor alpha

Synonyms

6430529J03Rik; AW259572; Erba; Nr1a1; Rvr; T3R[a]; T3Ralpha; Thra1; Thra2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099428

InnateDB Gene

IDBG-210748 (Thra)

Protein Structure

UniProt Annotation

Function

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha- deltaE6 does not bind DNA, inhibits the activity of isoform Alpha- 1, and stimulates myoblast differentiation. {ECO:0000269PubMed:16322094}.

Subcellular Localization

Nucleus.Isoform Alpha-deltaE6: Cytoplasm. Note=Sequesters isoform Alpha-1 into this compartment.

Disease Associations

Tissue Specificity

Ubiquitous (Isoform Alpha-deltaE6). {ECO:0000269PubMed:16322094}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	61 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002153	steroid receptor RNA activator RNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003727	single-stranded RNA binding
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004887	thyroid hormone receptor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0017025	TBP-class protein binding
GO:0019904	protein domain specific binding
GO:0031490	chromatin DNA binding
GO:0032403	protein complex binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0070324	thyroid hormone binding

Biological Process

GO:0001502	cartilage condensation
GO:0001503	ossification
GO:0002155	regulation of thyroid hormone mediated signaling pathway
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007611	learning or memory
GO:0008016	regulation of heart contraction
GO:0008050	female courtship behavior
GO:0009409	response to cold
GO:0009755	hormone-mediated signaling pathway
GO:0009887	organ morphogenesis
GO:0010831	positive regulation of myotube differentiation
GO:0017055	negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0030218	erythrocyte differentiation
GO:0030522	intracellular receptor signaling pathway
GO:0030878	thyroid gland development
GO:0033032	regulation of myeloid cell apoptotic process
GO:0042994	cytoplasmic sequestering of transcription factor
GO:0043401	steroid hormone mediated signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045925	positive regulation of female receptivity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050994	regulation of lipid catabolic process
GO:0060509	Type I pneumocyte differentiation
GO:2000143	negative regulation of DNA-dependent transcription, initiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:98742

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR001728 Thyroid hormone receptor
IPR003078 Retinoic acid receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR00546
PR01292

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt