InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plekha1

Summary

InnateDB Protein

IDBP-210861.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plekha1

Protein Name

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

Synonyms

AA960558; C920009D07Rik; TAPP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074675

InnateDB Gene

IDBG-210859 (Plekha1)

Protein Structure

UniProt Annotation

Function

Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030165	PDZ domain binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding

Biological Process

GO:0001553	luteinization
GO:0007283	spermatogenesis
GO:0008209	androgen metabolic process
GO:0008210	estrogen metabolic process
GO:0008585	female gonad development
GO:0009791	post-embryonic development
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0031529	ruffle organization
GO:0033327	Leydig cell differentiation
GO:0035264	multicellular organism growth
GO:0045184	establishment of protein localization
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048705	skeletal system morphogenesis
GO:0050853	B cell receptor signaling pathway
GO:0051898	negative regulation of protein kinase B signaling
GO:0060021	palate development
GO:0060325	face morphogenesis
GO:0070301	cellular response to hydrogen peroxide

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0032587	ruffle membrane

Protein Structure and Domains

PDB ID

MGI:2442213

InterPro

IPR001849 Pleckstrin homology domain

PFAM

PF00169

PRINTS

PIRSF

SMART

SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BUL6

PhosphoSite

PhosphoSite-Q8BUL6

TrEMBL

UniProt Splice Variant

Entrez Gene

101476

UniGene

Mm.473925

RefSeq

XP_006507210

MGI ID

MGI Symbol

Plekha1

OMIM

CCDS

HPRD

IMGT

EMBL

AK083340 BC020017

GenPept

AAH20017 BAC38874