InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Plekha1

Summary

InnateDB Gene

IDBG-210859.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plekha1

Gene Name

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

Synonyms

AA960558; C920009D07Rik; TAPP1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040268

Encoded Proteins

IDBP-210861

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

IDBP-210863

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

IDBP-400150

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

IDBP-533995

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

IDBP-541142

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107679:
This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:130865756-130913312

Strand

Forward strand

Band

Transcripts

ENSMUST00000075181	ENSMUSP00000074675
ENSMUST00000048180	ENSMUSP00000035375
ENSMUST00000120441	ENSMUSP00000112777
ENSMUST00000148513
ENSMUST00000140153
ENSMUST00000151119	ENSMUSP00000123600
ENSMUST00000154282
ENSMUST00000149029
ENSMUST00000136963
ENSMUST00000146111
ENSMUST00000126355	ENSMUSP00000114411
ENSMUST00000135359

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030165	PDZ domain binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding

Biological Process

GO:0001553	luteinization
GO:0007283	spermatogenesis
GO:0008209	androgen metabolic process
GO:0008210	estrogen metabolic process
GO:0008585	female gonad development
GO:0009791	post-embryonic development
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0031529	ruffle organization
GO:0033327	Leydig cell differentiation
GO:0035264	multicellular organism growth
GO:0045184	establishment of protein localization
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048705	skeletal system morphogenesis
GO:0050853	B cell receptor signaling pathway
GO:0051898	negative regulation of protein kinase B signaling
GO:0060021	palate development
GO:0060325	face morphogenesis
GO:0070301	cellular response to hydrogen peroxide

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0032587	ruffle membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000107679

View Gene Order

ENSBTAG00000004636

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_12

BCR pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.323554 Mm.473925

RefSeq

NM_133942 XM_006507145 XM_006507153

OMIM

CCDS

CCDS21907

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas