InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Src

Summary

InnateDB Protein

IDBP-211277.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Src

Protein Name

Rous sarcoma oncogene

Synonyms

AW259666; pp60c-src;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029175

InnateDB Gene

IDBG-211273 (Src)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 119 experimentally validated interaction(s) in this database.
They are also associated with 348 interaction(s) predicted by orthology.

Experimentally validated
Total	119 [view]
Protein-Protein	117 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	348 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005080	protein kinase C binding
GO:0005102	receptor binding
GO:0005158	insulin receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0020037	heme binding
GO:0030331	estrogen receptor binding
GO:0032403	protein complex binding
GO:0042169	SH2 domain binding
GO:0044325	ion channel binding
GO:0046875	ephrin receptor binding
GO:0050839	cell adhesion molecule binding
GO:0051219	phosphoprotein binding
GO:0070851	growth factor receptor binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008283	cell proliferation
GO:0009612	response to mechanical stimulus
GO:0009615	response to virus
GO:0010447	response to acidity
GO:0010628	positive regulation of gene expression
GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0010907	positive regulation of glucose metabolic process
GO:0014911	positive regulation of smooth muscle cell migration
GO:0016337	single organismal cell-cell adhesion
GO:0016477	cell migration
GO:0018105	peptidyl-serine phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030900	forebrain development
GO:0031667	response to nutrient levels
GO:0031954	positive regulation of protein autophosphorylation
GO:0032148	activation of protein kinase B activity
GO:0032463	negative regulation of protein homooligomerization
GO:0032869	cellular response to insulin stimulus
GO:0033146	regulation of intracellular estrogen receptor signaling pathway
GO:0034332	adherens junction organization
GO:0035556	intracellular signal transduction
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043393	regulation of protein binding
GO:0043406	positive regulation of MAP kinase activity
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045056	transcytosis
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045785	positive regulation of cell adhesion
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046628	positive regulation of insulin receptor signaling pathway
GO:0046777	protein autophosphorylation
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048477	oogenesis
GO:0050715	positive regulation of cytokine secretion
GO:0050847	progesterone receptor signaling pathway
GO:0051222	positive regulation of protein transport
GO:0051385	response to mineralocorticoid
GO:0051602	response to electrical stimulus
GO:0051895	negative regulation of focal adhesion assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0051902	negative regulation of mitochondrial depolarization
GO:0060065	uterus development
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070542	response to fatty acid
GO:0070555	response to interleukin-1
GO:0071222	cellular response to lipopolysaccharide
GO:0071393	cellular response to progesterone stimulus
GO:0071398	cellular response to fatty acid
GO:0071456	cellular response to hypoxia
GO:0071803	positive regulation of podosome assembly
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:1902533	positive regulation of intracellular signal transduction
GO:2000573	positive regulation of DNA biosynthetic process
GO:2000811	negative regulation of anoikis
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005764	lysosome
GO:0005770	late endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0014069	postsynaptic density
GO:0043005	neuron projection
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:98397

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM