InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acly

Summary

InnateDB Protein

IDBP-211438.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acly

Protein Name

ATP citrate lyase

Synonyms

A730098H14Rik; AW538652;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000007131

InnateDB Gene

IDBG-211434 (Acly)

Protein Structure

UniProt Annotation

Function

ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003878	ATP citrate synthase activity
GO:0004775	succinate-CoA ligase (ADP-forming) activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046872	metal ion binding
GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
GO:0048037	cofactor binding

Biological Process

GO:0006085	acetyl-CoA biosynthetic process
GO:0008152	metabolic process
GO:0008610	lipid biosynthetic process
GO:0044262	cellular carbohydrate metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:103251

InterPro

IPR002020 Citrate synthase-like
IPR003781 CoA-binding
IPR005811 ATP-citrate lyase/succinyl-CoA ligase
IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
IPR014608 ATP-citrate synthase
IPR016102 Succinyl-CoA synthetase-like
IPR016141 Citrate synthase-like, core

PFAM

PF00285
PF02629
PF13380
PF00549
PF08442

PRINTS

PR00143

PIRSF

PIRSF036511

SMART

SM00881

TIGRFAMs

Post-translational Modifications

Modification

Cross-References