Version 5.4
| Mus musculus Protein: Nkiras2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||
| InnateDB Protein | IDBP-211495.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Nkiras2 | ||||||||
| Protein Name | NFKB inhibitor interacting Ras-like protein 2 | ||||||||
| Synonyms | 2410003M04Rik; 4930527H08Rik; D630018G21Rik; KBRAS2; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000017981 | ||||||||
| InnateDB Gene | IDBG-211491 (Nkiras2) | ||||||||
| Protein Structure |
|
||||||||
| UniProt Annotation | |||||||||
| Function | Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF- kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cytoplasm {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
|
||||||||
| Gene Ontology | |||||||||
Molecular Function |
|
||||||||
| Biological Process |
|
||||||||
| Cellular Component |
|
||||||||
| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1919216 | ||||||||
| InterPro |
IPR001806
Small GTPase superfamily IPR003579 Small GTPase superfamily, Rab type IPR005225 Small GTP-binding protein domain IPR006689 Small GTPase superfamily, ARF/SAR type IPR013684 Mitochondrial Rho-like IPR020849 Small GTPase superfamily, Ras type IPR027417 P-loop containing nucleoside triphosphate hydrolase |
||||||||
| PFAM |
PF00071
PF00025 PF08477 |
||||||||
| PRINTS |
PR00449
PR00328 |
||||||||
| PIRSF | |||||||||
| SMART |
SM00175
SM00173 |
||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9CR56 | ||||||||
| PhosphoSite | PhosphoSite-Q9CR56 | ||||||||
| TrEMBL | F6XZA4 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 71966 | ||||||||
| UniGene | Mm.485819 | ||||||||
| RefSeq | NP_082300 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Nkiras2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS25429 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK010371 AK015918 AK052645 AK083475 AK149696 AK169878 AL591469 BC013469 BC024398 | ||||||||
| GenPept | AAH13469 AAH24398 BAB26889 BAB30030 BAC35078 BAC38929 BAE29033 BAE41430 | ||||||||