Version 5.4
Mus musculus Gene: Nkiras2
Summary
InnateDB Gene IDBG-211491.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nkiras2
Gene Name NFKB inhibitor interacting Ras-like protein 2
Synonyms 2410003M04Rik; 4930527H08Rik; D630018G21Rik; KBRAS2
Species Mus musculus
Ensembl Gene ENSMUSG00000017837
Encoded Proteins
IDBP-211493
NFKB inhibitor interacting Ras-like protein 2
IDBP-211495
NFKB inhibitor interacting Ras-like protein 2
IDBP-266810
NFKB inhibitor interacting Ras-like protein 2
IDBP-538546
NFKB inhibitor interacting Ras-like protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20351193
[Homo sapiens] NKIRAS2 is a key inhibitor of NF-kappaB signalling and estradiol represses NF-kappaB activation through the induction of NKIRAS2.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168256:
Gene Information
Type Protein coding
Genomic Location Chromosome 11:100619244-100627607
Strand Forward strand
Band D
Transcripts
ENSMUST00000051947 ENSMUSP00000059559
ENSMUST00000017981 ENSMUSP00000017981
ENSMUST00000107376 ENSMUSP00000102999
ENSMUST00000127547
ENSMUST00000155840
ENSMUST00000142993 ENSMUSP00000114456
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000168256
View Gene Order
ENSBTAG00000002657
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9CR56
TrEMBL F6XZA4
UniProt Splice Variant
Entrez Gene 71966
UniGene Mm.437214 Mm.485819
RefSeq NM_028024
OMIM
CCDS CCDS25429
HPRD
IMGT
MGI ID MGI:1919216
MGI Symbol Nkiras2
EMBL AK010371 AK015918 AK052645 AK083475 AK149696 AK169878 AL591469 BC013469 BC024398
GenPept AAH13469 AAH24398 BAB26889 BAB30030 BAC35078 BAC38929 BAE29033 BAE41430
RNA Seq Atlas 71966

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca