InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hcrt

Summary

InnateDB Protein

IDBP-211587.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hcrt

Protein Name

hypocretin

Synonyms

PPOX;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057578

InnateDB Gene

IDBG-211585 (Hcrt)

Protein Structure

UniProt Annotation

Function

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.

Subcellular Localization

Rough endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000250}.

Disease Associations

Tissue Specificity

Restricted to neuronal cell bodies of the dorsal and lateral hypothalamus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0031771	type 1 hypocretin receptor binding
GO:0031772	type 2 hypocretin receptor binding

Biological Process

GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007631	feeding behavior
GO:0008156	negative regulation of DNA replication
GO:0042755	eating behavior
GO:0043267	negative regulation of potassium ion transport
GO:0046928	regulation of neurotransmitter secretion
GO:0051928	positive regulation of calcium ion transport
GO:0051970	negative regulation of transmission of nerve impulse
GO:0051971	positive regulation of transmission of nerve impulse
GO:0060079	regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005737	cytoplasm
GO:0005791	rough endoplasmic reticulum
GO:0030054	cell junction
GO:0030141	secretory granule
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm