Version 5.4
Mus musculus Gene: Hcrt
Summary
InnateDB Gene IDBG-211585.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hcrt
Gene Name hypocretin
Synonyms PPOX
Species Mus musculus
Ensembl Gene ENSMUSG00000045471
Encoded Proteins
IDBP-211587
hypocretin
IDBP-266833
hypocretin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161610:
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:100761069-100762931
Strand Reverse strand
Band D
Transcripts
ENSMUST00000055083 ENSMUSP00000057578
ENSMUST00000107360 ENSMUSP00000102983
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0031771 type 1 hypocretin receptor binding
GO:0031772 type 2 hypocretin receptor binding
Biological Process
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007631 feeding behavior
GO:0008156 negative regulation of DNA replication
GO:0042755 eating behavior
GO:0043267 negative regulation of potassium ion transport
GO:0046928 regulation of neurotransmitter secretion
GO:0051928 positive regulation of calcium ion transport
GO:0051970 negative regulation of transmission of nerve impulse
GO:0051971 positive regulation of transmission of nerve impulse
GO:0060079 regulation of excitatory postsynaptic membrane potential
Cellular Component
GO:0005737 cytoplasm
GO:0005791 rough endoplasmic reticulum
GO:0030054 cell junction
GO:0030141 secretory granule
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000161610
View Gene Order
ENSBTAG00000000665
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_231434
Orexin and neuropeptides FF and QRFP bind to their respective receptors pathway
REACT_231468
GPCR ligand binding pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_16973
Orexin and neuropeptides FF and QRFP bind to their respective receptors pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
REACT_205036
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_219025
Peptide ligand-binding receptors pathway
REACT_205369
Signaling by GPCR pathway
REACT_214353
Signal Transduction pathway
REACT_209521
G alpha (q) signalling events pathway
REACT_214436
GPCR downstream signaling pathway
REACT_220217
GPCR ligand binding pathway
REACT_208412
Class A/1 (Rhodopsin-like receptors) pathway
REACT_205260
Orexin and neuropeptides FF and QRFP bind to their respective receptors pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O55241
TrEMBL Q547R2
UniProt Splice Variant
Entrez Gene 15171
UniGene Mm.10096
RefSeq NM_010410
OMIM
CCDS CCDS25436
HPRD
IMGT
MGI ID MGI:1202306
MGI Symbol Hcrt
EMBL AF019566 AF041242 AF458960 BC116943 BC116969 CH466662
GenPept AAC02934 AAC40040 AAI16944 AAI16970 AAL60241 EDL02533
RNA Seq Atlas 15171

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca