InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zhx3

Summary

InnateDB Protein

IDBP-211649.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zhx3

Protein Name

zinc fingers and homeoboxes 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099401

InnateDB Gene

IDBG-211647 (Zhx3)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.

Subcellular Localization

Nucleus {ECO:0000250UniProtKB:Q9H4I2, ECO:0000255PROSITE-ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:14659886}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030154	cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated